Bivariate network meta‐analysis for surrogate endpoint evaluation

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition.

A common problem of interest within a randomized clinical trial is the evaluation of an inexpensive response endpoint as a valid surrogate endpoint for a clinical endpoint, where a chief purpose of a valid surrogate is to provide a way to make correct inferences on clinical treatment effects in future studies without needing to collect the clinical endpoint data. Within the principal stratifica...

متن کامل

Surrogate endpoint analysis: an exercise in extrapolation.

Surrogate endpoints offer the hope of smaller or shorter cancer trials. It is, however, important to realize they come at the cost of an unverifiable extrapolation that could lead to misleading conclusions. With cancer prevention, the focus is on hypothesis testing in small surrogate endpoint trials before deciding whether to proceed to a large prevention trial. However, it is not generally app...

متن کامل

Neurocognitive function: an emerging surrogate endpoint for neuro-oncology trials.

Pediatric neuro-oncologists are familiar with the challenge that their potentially curative treatments may come at a high price because they may improve survival, but not without developmental delays and persistent neuropsychological sequelae in a significant proportion of patients. The view that the radiological determination of response or stable disease is a sufficient parameter to ascertain...

متن کامل

Is critical care ready for an economic surrogate endpoint?

Intensive care is expensive, and thus a body of research has focused on strategies to reduce its costs. However, efforts to reduce the total cost of intensive care have met with limited success, partly because of the challenges of calculating how much a day in the ICU actually costs. We discuss these challenges and introduce the concept of total cost savings as an outcome of critical care trial...

متن کامل

Surrogate endpoint biomarkers for cervical cancer chemopreventive trials.

Cervical intraepithelial neoplasia (CIN) represents a spectrum of epithelial changes that provide an excellent model for developing chemopreventive interventions for cervical cancer. Possible drug effect surrogate endpoint biomarkers are dependent on the agent under investigation. Published and preliminary clinical reports suggest retinoids and carotenoids are effective chemopreventive agents f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Statistics in Medicine

سال: 2019

ISSN: 0277-6715,1097-0258

DOI: 10.1002/sim.8187